OPUS® MiniChrom® Pre-packed Column 5 mL Volume with AVIPure® dsRNA Clear Resin. AVIPure dsRNA Clear OPUS prepacked columns is the first and only bead based, affinity chromatography solution for removing dsRNA impurities from mRNA preparations. The solution is targeted, eliminates the use of organic solvents (EtOH), negates the need for a non-specific and non-scalable removal methods and sets the standard for dsRNA impurity clearance in mRNA production processes.