The new CaptivA® HF (High Flow) Affinity Resin is a highly cross-linked agarose-based Protein A affinity resin designed for bind and elute, process scale capture chromatography for the purification of Fc-fusion proteins and monoclonal antibodies (mAbs). CaptivA® HF Protein A Affinity Resin is designed to have similar performance characteristics to CaptivA® PriMAB Protein A Affinity Resin (legacy) with improved pressure-flow performance. Both resins utilize Repligen’s rSPA recombinant, Protein A ligand, which is animal origin free. CaptivA HF employs a hardened agarose bead which enables higher flow rates at taller bed heights resulting in a cost-effective and higher-performing Protein A affinity resin.